Evaluation of hepatic function with 13C-methacetin breath test in patients with liver cirrhosis

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13C-methacetin breath test correlates with clinical indices of liver disease severity in patients with primary biliary cirrhosis.

This prospective study intended to ascertain if cytochrome P450 dependent liver function is affected in early and late histological stages of primary biliary cirrhosis (PBC). The study included 32 female PBC patients (mean age 55.4 years, range 33-70) and 16 aged-matched healthy women (mean age 52.6 years, range 38-65). In every subject a 13(C)-methacetin breath test (13(C)-MBT) was applied, an...

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13C Methacetin Breath Test for Assessment of Microsomal Liver Function: Methodology and Clinical Application

Assessment of the liver function, and the need of constant monitoring of the organ's capacity, concerns not only patients with primary liver diseases, but also those at risk of hepatopathies secondary to other chronic diseases. Most commonly, the diagnostics is based on measurements of static biochemical parameters, which allow us to draw conclusions only indirectly about the function and the d...

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Role of 13C methacetin breath test for non invasive staging of liver fibrosis in patients with chronic hepatitis C

BACKGROUND & OBJECTIVES The development and evaluation of non invasive tests to assess liver fibrosis have been an active field of research. The present study was carried out to evaluate the role of 13C-methacetin breath test 13C-MBT) as a non invasive tool for liver fibrosis staging in patients with chronic hepatitis C (CHC). METHODS 13C-Methacetin breath test was performed in 115 patients w...

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Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease

The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, neg...

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ژورنال

عنوان ژورنال: World Chinese Journal of Digestology

سال: 2004

ISSN: 2219-2859

DOI: 10.11569/wcjd.v12.i9.2147